Emfietzoglou Dimitris, Ph.D.
University of
Ioannina GR-45110
Fax: (30) 26510 07854
e-mail: demfietz@cc.uoi.gr
Biographical
Sketch
1991 BSc
(Physics),
1993 MSc
(Radiation Science),
1996 PhD (Radiation Biophysics),
1999 Post Doctoral Fellow,
2000 Lecturer, Medical
Physics Laboratory,
2005-present Assistant Professor, Medical Physics
Laboratory, University of Ioannina Medical
School,
Research
ˇ Interaction of charged-particle beams with bulk matter and
nanostructures with special interest in the energy-loss of electrons, protons,
and α-particles
to electronic excitations in biological materials (liquid water, organic
solids, DNA) and carbon nanotubes.
ˇ
Group Members
Post-doctoral
researchers
Ioanna Kyriakou
(PhD, Physics Dept.,
Christos Bousis
(PhD, Medical Physics Lab,
PhD students
George Papamichael (Applied Mathematics Dept.,
Christos Bousis (Medical Physics Lab,
Master students
Kostas Skordos (Medical Physics Lab,
Alexandros Papakostas (Medical
Physics Lab,
Kostantina Karava (Medical Physics Lab,
Dimos Dimopoulos (Medical Physics Lab,
Undergraduate students
Vasilis Kostakis
(
Kostas Zogopoulos (Physics Dept.,
Marios Sotiropoulos (Physics Dept.,
Christos Laggouras (Physics Dept.,
Research Programs (Total funding:
approx. 300k EUR)
Industrial
Sponsorship 2002-2005
Center
for Drug Delivery Research (
European
Commission (FP7) 2008-2011
Ministry
of Science and Innovation (
(ISI: 900+ citations, h-index: 17)
1. Akselrod M., McKeever S.W.S., Moscovitch M., Emfietzoglou D., Durham J.S., Soares C.G. A thin layer Al2O3:C beta
TL detector. Radiation Protection Dosimetry 66:105-110 (1996)
2. Emfietzoglou
D. and Moscovitch M. Phenomenological study
of light-induced effects in a-Al2O3:C. Radiation Protection Dosimetry
65:259-262 (1996)
3. Otero G., Avila M.A., Emfietzoglou D., Clerch L.B., Massaro D., Notario V. Increased manganese superoxide dismutase
activity, protein and mRNA and concurrent induction of tumor necrosis factor a
in radiation initiated syrian hamster cells. Molecular Carcinogenesis 17:175-180
(1996)
4. Otero G., Avila M.A., Pena L., Emfietzoglou D., Cansado J., Popescu G.F., Notario V. Altered processing of precursor transcripts and
increased levels of the subunit I of mitochondrial cytochrome
c oxidase in syrian hamster
fetal cells initiated with ionizing radiation. Carcinogenesis 18:1569-1575 (1997)
5. Moscovitch M.
and Emfietzoglou D. Simulation
of radiation effects on three-dimensional computer optical memories. Journal of Applied Physics 81:58-69
(1997)
6. Emfietzoglou
D. and Moscovitch M. A potential application
to the study of microscopic energy deposition in a solid by means of heavy
charged-particle induced photochromic alterations in
a tissue-equivalent matrix. Physics in
Medicine and Biology 44:207-221 (1999)
7.
Kostarelos K., Emfietzoglou D., Stamatelou M. Liposome-mediated delivery of radionuclides to tumor models for cancer radiotherapy: a
quantitative analysis. Journal of
Liposome Research 9:407-424 (1999)
8. Kostarelos K.
and Emfietzoglou D. Liposomes as carriers of radionuclides:
from imaging to therapy (REVIEW). Journal
of Liposome Research 9:429-460 (1999)
9. Emfietzoglou
D., Papamichael G., Moscovitch
M. An event-by-event computer simulation of interactions of energetic
charged-particles and all their secondary electrons in water. Journal of Physics D: Applied Physics
33:932-944 (2000)
10. Emfietzoglou
D., Papamichael G., Kostarelos
K., Moscovitch M. A Monte-Carlo track structure code
for electrons (~10 eV-10 KeV)
and protons (~0.3-10 MeV) in water: partitioning of energy
and collision events. Physics in Medicine
and Biology 45:3171-3194 (2000)
11. Kostarelos K.
and Emfietzoglou D.
Tissue dosimetry of liposome-radionuclide complexes
for internal radiotherapy: toward liposome-targeted therapeutic
radiopharmaceuticals. Anticancer Research
20:3339-3346 (2000)
12. Emfietzoglou
D., Papamichael G., Moscovitch
M. Monte Carlo simulation of charged particle transport in biomatter.
Physica Medica
17:113-114 (2001)
13. Emfietzoglou
D., Papamichael G., Moscovitch
M. Charged particle interactions in water: cross sections and simulations. Radiation Physics and Chemistry
61:597-598 (2001).
14. Emfietzoglou
D., Kostarelos
K., Sgouros G. An analytic dosimetry
study for the use of radionuclide-liposome conjugates in internal radiotherapy.
Journal of Nuclear Medicine
42:499-504 (2001)
15. Emfietzoglou
D. Semi-empirical inelastic cross-sections for electron transport in
liquid water. Radiation Protection Dosimetry 99:39-46 (2002)
16. Emfietzoglou
D. and Moscovitch M. Inelastic collision
characteristics of electrons in liquid water. Nuclear Instruments and Methods in Physics Research Section B: Beam
Interactions with Materials and Atoms 193:71-78 (2002)
17. Emfietzoglou
D. Modeling the energy-loss mechanism of charged particles in organic
solids. Radiation Protection Dosimetry 100:153-158 (2002)
18. Moscovitch M.,
Phillips G.W., Cullum B.M., Mobley J., Bogard J.S., Emfietzoglou
D., Vo-Dinh T. Radiation dosimetry
using three-dimensional optical random access memories. Radiation Protection Dosimetry 101:17-22
(2002)
19. Emfietzoglou
D. Inelastic Cross-sections for electron transport in liquid water: a
comparison of dielectric models. Radiation
Physics and Chemistry 66:373-385 (2003)
20. Emfietzoglou
D. and Moscovitch M. Secondary electron
spectra for fast proton impact on gaseous and liquid water. Nuclear Instruments and Methods in Physics
Research Section B: Beam Interactions with Materials and Atoms 209:239-245
(2003)
21. Emfietzoglou
D., Karava K., Papamichael
G., Moscovitch M. Monte-Carlo simulation of the
energy-loss of low-energy electrons in liquid water. Physics in Medicine and Biology 48:2355-2371 (2003)
22. Emfietzoglou
D., Moscovitch M, Pathak
A. Inelastic cross-sections of energetic protons in liquid water calculated by
model dielectric functions and optical data. Nuclear Instruments and Methods in Physics Research Section B: Beam
Interactions with Materials and Atoms 212:101-109 (2003)
23. Emfietzoglou
D., Karava K., Papamichael
G., Moscovitch M.
Monte-Carlo calculations of radial dose and restricted-LET for protons
in water. Radiation Protection Dosimetry 110:871-879 (2004)
24. Kostarelos
K.,
Emfietzoglou D.,
Papakostas A., Yang
W-H
, Ballangrud
A.,
Sgouros G. Binding
and
interstitial
penetration
of
liposomes within avascular
tumor
spheroids.
International
Journal
of Cancer 112:713-721
(2004)
25. Emfietzoglou D., Akkerman A., Barak J. New Monte-Carlo
calculations of charged particles track-structure in silicon. IEEE Transactions on Nuclear Science 51:2872-2879 (2004)
26. Kostarelos K., Emfietzoglou D., Tadros
T.F. Light-sensitive fusion between polymer-coated liposomes
following physical anchoring of di-block copolymers
onto lipid bilayers by self-assembly. Faraday
Discussions 128:379-388 (2005).
27. Emfietzoglou
D., Nikjoo H. The effect of model approximations
on single-collision distributions of low-energy electrons in liquid water. Radiation
Research 163:98-111 (2005)
28. Akkerman A., Barak J., Emfietzoglou
D. Ion and electron track-structure and its effects in silicon: model
and calculations. Nuclear Instruments and
Methods in Physics Research Section B: Beam Interactions with Materials and
Atoms 227:319-336 (2005)
29. Emfietzoglou
D., Kostarelos K., Papakostas
A., Yang W-H., Ballangrud A., Song H., Sgouros G. Liposome-mediated radiotherapeutics
within avascular tumor spheroids: comparative dosimetry study for various radionuclides,
liposome systems and a targeting antibody. Journal
of Nuclear Medicine 46:89-97 (2005)
30. Emfietzoglou D.,
Papamichael G., Androulidakis
I., Karava K., Kostarelos
K., Pathak A., Moscovitch
M. A Monte-Carlo study of sub-keV electron transport
in water: the influence of the condensed-phase. Nuclear
Instruments and Methods in Physics Research Section B: Beam Interactions with
Materials and Atoms 228:341-348 (2005)
31. Emfietzoglou D.,
Pathak A., Moscovitch M. Modeling the energy and
momentum dependent loss function of the valence shells of liquid water. Nuclear Instruments and Methods in Physics
Research Section B: Beam Interactions with Materials and Atoms 230:77-84
(2005)
33. Kostarelos K., Emfietzoglou
D., Papakostas A., Yang W-H., Ballangrud A., Sgouros G.
Engineering lipid vesicles of enhanced intratumoral
transport capabilities: correlating liposome characteristics with penetration
into human prostate tumor spheroids. Journal of Liposome Research
15:15-27 (2005)
34. Hindorf C., Emfietzoglou D.,
Linden O., Kostarelos K., Strand S-E. Internal microdosimetry for single cells in radioimmunotherapy
of B-cell lymphoma. Cancer Biotherapy and Radiopharmaceuticals
20:224-230 (2005)
35. Emfietzoglou
D., Cucinotta F.A., Nikjoo
H. A complete dielectric response model for liquid water A solution of the Bethe
ridge problem. Radiation Research 164:202-211 (2005)
36. Dhamodaran S., Sathish N., Pathak A. Nageswara Rao S.V.S., Siddiqui A.M., Khan
38. Emfietzoglou
D., Paganetti H., Papamichael
G., Pathak A. Monte Carlo calculation of nanoscale dosimetric
distributions of MeV proton tracks with secondary
electron transport. Nuclear Instruments
and Methods in Physics Research Section B: Beam Interactions with Materials and
Atoms 245:80-84 (2006)
39. Emfietzoglou
D., Nikjoo H. Papamichael
G., Pathak A. Proton beam profiling in soft
biological matter by detailed Monte Carlo simulation. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions
with Materials and Atoms, 249:670-672 (2006)
40. Emfietzoglou
D., Nikjoo H., Pathak
A. Electronic cross sections for proton transport in liquid water based on
optical-data models. Nuclear Instruments
and Methods in Physics Research Section B: Beam Interactions with Materials and
Atoms 249:26-28 (2006)
41. Dhamodaran
S., Sathish N., Pathak A.,
Khan S.A., Avasthi D.K., Srinivasan
T., Muralidharan R., Kesavamoorthy
R., Emfietzoglou D. Raman
and AFM studies of swift heavy ion irradiated InGaAs/GaAs
heterostructures. Journal
of Physics: Condensed Matter 18:4135-4142 (2006)
42. Berillis P., Emfietzoglou D., Tzaphlidou M. Collagen fibril diameter in relation to bone
site and to calcium/phosphorus ratio. TheScientificWorldJournal
6:1109-1113 (2006)
43. Emfietzoglou D., Papamichael G., Karava K., Androulidakis I., Pathak A.,
Phillips G.W., Moscovitch M., Kostarelos
K. A Monte-Carlo code for the detailed simulation of electron and light-ion
tracks in condensed matter. Radiation Protection Dosimetry, 119:491-496 (2006)
44. Phillips G.W., Span J., Bogard J.S., VoDinh T., Emfietzoglou D., Devine R., Moscovitch M. Neutron spectrometry using CR-39 track etch
detectors. Radiation Protection Dosimetry 120:457-460 (2006)
45. Nikjoo H., Uehara S., Emfietzoglou
D., Cucinotta F.A. Monte Carlo track
structure codes in radiation research - A review. Radiation Measurement 41:1052-1074 (2006)
46. Emfietzoglou D., Nikjoo
H., Pathak A. A comparative study of dielectric response
function models for liquid water. Radiation
Protection Dosimetry 122 :61-65 (2006)
47. Emfietzoglou D., Nikjoo
H. Accurate electron inelastic cross sections and stopping powers for liquid
water over the 0.1-10 keV range based on an improved
dielectric description of the Bethe surface. Radiation
Research 167:110-120 (2007)
48. Dhamodaran
S., Sathish N., Pathak
A.P., Avasthi D.K., Muralidharan
R., Sundaravel B., Nair K.G.M., Sridhara
Rao D.V., Muraleedharan K., Emfietzoglou
D. Ion beam analysis of defects and strain in heavy ion irradiated InGaAs/GaAs heterostructures. Nuclear Instruments and Methods in Physics
Research Section B: Beam Interactions with Materials and Atoms 254:283-288
(2007)
49. Emfietzoglou
D., Bousis C., Hindorf
C., Fotopoulos A., Pathak, Kostarelos
K. A Monte Carlo study of energy deposition at the sub-cellular level for
application to targeted radionuclide therapy with low-energy electron emitters.
Nuclear Instruments and Methods in Physics Research
Section B: Beam Interactions with Materials and Atoms 256:547-553
(2007)
50. George J., Pathak
A., Emfietzoglou D.
Quantum calculations for the effects of
dislocations on channeling and channeling radiation. Nuclear Instruments and Methods in Physics
Research Section B: Beam Interactions with Materials and Atoms 256:148-152
(2007)
51. Emfietzoglou
D., Nikjoo H., Petsalakis
I.D., Pathak A. A consistent dielectric response
model for water ice over the whole energy-momentum plane. Nuclear Instruments and Methods in Physics Research Section B: Beam
Interactions with Materials and Atoms 256:141-147 (2007)
52. Emfietzoglou D., Nikjoo
H., Pathak A., Sathish N. A
comparison of secondary electron spectra from proton-impact ionization on water
in the liquid and solid phases. Nuclear Instruments
and Methods in Physics Research Section B: Beam Interactions with Materials and
Atoms 257:609-613 (2007)
53. Dhamodaran S, Pathak A.P., Avasthi D.K., Srinivasan T., Muralidharan
R. Emfietzoglou D. Surface Modification of InGaAs/GaAs Heterostructures by
Swift Heavy Ion Irradiation. Nuclear
Instruments and Methods in Physics Research Section B: Beam Interactions with
Materials and Atoms 257:301-306 (2007)
54. Hindorf C., Emfietzoglou D., Linden O., Bousis C., Fotopoulos A., Kostarelos
K., Flux G. Single cell dosimetry for radioimmunotherapy of B-cell lymphoma patients with special
reference to leukaemic spread. Cancer Biotherapy
and Radiopharmaceuticals 22:357-366 (2007)
55. Emfietzoglou
D., Papamichael G., Pathak
A., Fotopoulos A., Nikjoo H. Monte Carlo study of
energy deposition by heavy charged-particles in sub-cellular volumes. Radiation Protection Dosimetry
126:457-462 (2007).
56. Emfietzoglou
D., Nikjoo H., Pathak
A. Electronic stopping power of liquid water for protons down to the Bragg peak.
Radiation Protection Dosimetry
126:97-100 (2007).
57. Lacerda L., Soundararajan A., Pastorin G.,
Al-Jamar K., Turton J., Frederik P., Herrero M.A., Li S.,
Bao A., Emfietzoglou
D., Mather S., Phillips W.T., Prato M., Goins
B., Kostarelos K. Dynamic Imaging of functionalized
multi-walled carbon nanotube systemic circulation
& urinary excretion. Advanced
Materials 20:225-230 (2008)
58. Pathak A.P., Sathish N., Dhamodaran S., Emfietzoglou D. Study of GaAs
and GaN based heterostructure
surfaces and interfaces using ion beams and other complementary techniques. Vacuum 82:911-921 (2008)
59. Bousis C., Emfietzoglou D., Hadjidoukas
P., Nikjoo H., Pathak A.
Electron ionization cross section calculations for liquid water at high impact
energies. Nuclear Instruments and Methods
in Physics Research Section B: Beam Interactions with Materials and Atoms 266:1185-1192 (2008).
60. Emfietzoglou
D., Abril I., Garcia-Molina R., Petsalakis I.D., Nikjoo H., Kyriakou I., Pathak A.
Semi-empirical dielectric descriptions of the Bethe surface of the valence
bands of condensed water. Nuclear
Instruments and Methods in Physics Research Section B: Beam Interactions with
Materials and Atoms 266:1154-1161
(2008)
61. Bousis C., Emfietzoglou D., Hadjidoukas
P., Nikjoo H. A
62. Nikjoo
Η.
Uehara S, Emfietzoglou D., Brahme
A. Heavy charged particles in radiation biology and biophysics. New Journal of Physics 10:075006 (2008)
63. Nikjoo H., Emfietzoglou D., Watanabe R.,
Uehara S. Can
64. Emfietzoglou
D., Kostarelos
K., Hadjidoukas P., Bousis
C., Fotopoulos A., Pathak A., Nikjoo
H. Subcellular S-values for low energy
electrons: A comparison of Monte Carlo simulations and continuous slowing down
calculations. International Journal of
Radiation Biology 84:1034-1044 (2008)
65. Nikjoo H., Emfietzoglou D., Charlton D.E. The Auger
effect in physical and biological research. International
Journal of Radiation Biology 84:1011-1026 (2008)
66. Emfietzoglou
D., Kyriakou I., Abril I., Garcia-Molina R., Petsalakis I.D., Nikjoo H., Pathak A. Electron inelastic mean free paths in biological
matter based on dielectric theory and local-field corrections. Nuclear Instruments and Methods in Physics
Research Section B: Beam Interactions with Materials and Atoms 267:45-52
(2009)
67. Bousis C., Emfietzoglou D., Nikjoo
H., Hadjidoukas P., Pathak
A. The effects of energy-loss straggling and elastic-scattering models on Monte
Carlo calculations of dose distribution functions for 10 keV
to 1 MeV incident electrons in water. Nuclear Instruments and Methods in Physics
Research Section B: Beam Interactions with Materials and Atoms
267:1725-1732 (2009)
68. Emfietzoglou
D., Garcia-Molina R., Kyriakou I., Abril I., Nikjoo H. A dielectric
response study of the electronic stopping power of liquid water for energetic
protons and a new I-value for water. Physics
in Medicine and Biology 54:3451-3472 (2009)
69. Garcia-Molina R., Abril
I., Denton C.D., Heredia-Avalos S., Kyriakou I., Emfietzoglou D. Calculated depth-dose
distributions for H+ and He+ beams in liquid water. Nuclear Instruments and Methods in Physics
Research Section B: Beam Interactions with Materials and Atoms
267:2647-2652 (2009)
70. Kyriakou I., Emfietzoglou D., Garcia-Molina R., Abril I., Kostarelos K. Electron
inelastic mean free path for carbon nanotubes from
optical data. Applied Physics Letters
94:263113-1-3 (2009)
71. Bousis C., Emfietzoglou D., Hadjidoukas
P., Nikjoo H. A Monte Carlo study of cellular
S-factors for 1 keV to 1 MeV
electrons. Physics in Medicine and
Biology 54:5023-5038 (2009)
72. Hadjidoukas P.,
Bousis C., Emfietzoglou
D. Parallelization of a Monte-Carlo particle transport simulation code.
Computer Physics Communications 181:928-936 (2010)
73. Sathish N., Kyriakou,
74.
75. Kyriakou I., Celedón C., Segura R., Emfietzoglou D., Vargas P., Valdés J.E., Abril I., Denton
C.D., Kostarelos K., Garcia-Molina R. Energy loss of
protons in carbon nanotubes: experiments and
calculations. Nuclear Instruments and
Methods in Physics Research Section B: Beam Interactions with Materials and
Atoms 268:1781-1785 (2010)
76. Bousis C., Emfietzoglou D., Hadjidoukas
P., Nikjoo H. Monte Carlo single-cell dosimetry of Auger-electron emitting radionuclides.
Physics in Medicine and Biology 55:2555-2572 (2010)
77. Emfietzoglou D., Kyriakou
I., Garcia-Molina R., Abril I., Kostarelos
K. Analytic expressions for the inelastic scattering and energy loss of
electron and proton beams in carbon nanotubes. Journal of Applied Physics 108:054312
(2010)
78. Nikjoo
H., Uehara S., Emfietzoglou
D., Pinsky L. A database of frequency distributions of energy
depositions in small-size targets by electrons and ions. Radiation Protection Dosimetry 143:145-151 (2011)
79. Liamsuwan T.,
Uehara S., Emfietzoglou D.,
Nikjoo H. A model for carbon ion
interactions in water using the classical trajectory
80. Liamsuwan
T., Uehara S., Emfietzoglou D.,
Nikjoo H. Physical and biophysical properties
of proton tracks of energies 1 keV to 300 MeV in water. International Journal of Radiation Biology 87:141-160
(2011)
81. Abril I.,
Garcia-Molina R., Denton C.D., Kyriakou I., Emfietzoglou D. Energy loss of H and He
beams in DNA: calculations based on a realistic energy loss function of the
target. Radiation Research 175:247-255 (2011)
82. Bousis C., Emfietzoglou D., Hadjidoukas P., Nikjoo H., Pathak A. Monte Carlo calculations of low-energy electron
dose-point-kernels in water
using different stopping power
Approximations. Nuclear
Instruments and Methods in Physics Research Section B: Beam Interactions with
Materials
and Atoms 269:1650-1654 (2011)
83. Kyriakou I., Emfietzoglou D., Garcia-Molina R., Abril I., Kostarelos K. Simple
model of bulk and surface excitation effects to inelastic scattering in
low-energy electron beam irradiation of multi-walled carbon nanotubes.
Journal of Applied Physics 110:054304
(2011)
84. Garcia-Molina R., Abril I., Heredia-Avalos S., Kyriakou I., Emfietzoglou D. A combined Molecular
Dynamics and
85. Emfietzoglou
D.,
86. Horowitz Y., Sibony D., Oster L., Livingstone
J., Guatelli S., Rosenfeld A., Emfietzoglou D., Bilski
P., Obryk B. Alpha particle and proton relative thermoluminescence efficiencies in LiF:Mg,Cu,P:
Is track structure theory up to the task ? Radiation Protection Dosimetry (in press)
87. Saikiran V., Pathak A.P., Srinivasa Rao N., Devaraju G., Debgupta J., Pillai V.K, Kyriakou I., Emfietzoglou
D. SHI irradiation induced effects in functionalized MWCNTs. Radiation
Effects and Defects in Solids (in
press)
* Bousis C., Emfietzoglou D., Nikjoo
H. Monte Carlo single-cell dosimetry of I-131, I-125
and I-123 for targeted radioimmunotherapy of B-cell
Lymphoma. (submitted)
* Bousis C., Emfietzoglou D., Nikjoo
H. Calculations of absorbed fractions in small water spheres for low-energy monoenergetic electrons and the Auger-emitting radionuclides 123I and 125I. (submitted)
* Liamsuwan
T., Emfietzoglou D., Uehara
S., Nikjoo H. Microdosimetry of
low-energy electrons. (submitted)
* Kalantzis
G., Emfietzoglou D., Hadjidoukas
P. A unified spatio-temporal parallelization framework
for accelerated Monte Carlo radiobiological modeling of electron tracks and
subsequent radiation chemistry (submitted)
* Emfietzoglou D., Kyriakou
I., Garcia-Molina R., Abril I., Kostarelos
K. Quasi first-principles Monte Carlo modeling of energy dissipation by
low-energy electron beams in multi-walled carbon nanotube
materials (submitted)

