Research Grants

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    European Union (European Regional Development Fund- ERDF) and Greek national funds through the Operational Program “THESSALY- MAINLAND GREECE AND EPIRUS-2007-2013” of the National Strategic Reference Framework (NSRF 2007-2013) | Grant

    Principal Investigator

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    Scholarship Programme "Heraclitus II" Heraclitus II - Enhancing Human Research Potential through Doctoral Research

    Participant

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Evaluation of the 3D spatial distribution of the Calcium/Phosphorus ratio in bone using computed-tomography dual-energy analysis

Hadjipanteli, A., Kourkoumelis, N., Fromme, P., Huang, J., Speller, R.
Journal Paper (2016) Physica Medica: European Journal of Medical Physics, Vol. 32, Issue 1, p162–168

The effect of irradiance and integration time in in vivo normal skin Raman measurements assessed by multivariate statistical analysis.

Aspasia Elka, Violetta Moulia, Panagiota Spyridonos, Nikolaos Kourkoumelis
Journal Paper (2016) Biomedical Spectroscopy and Imaging 5 (2016) 217–223

Novel bismuth compounds; Synthesis, characterization and biological activity against human adenocarcinoma cells

Sotiris K Hadjikakou, I. I. Ozturk, C N Banti, Nikolaos Kourkoumelis, Maria Manoli, Anastasios Tasiopoulos, M Arda
Journal Paper (2016) RSC Advances 03/2016

New antimony(III) halide complexes with dithiocarbamate ligands derived from thiuram degradation: The effect of the molecule's close contacts on in vitro cytotoxic activity

Urgut, O.S., Ozturk, I.I., Banti, C.N., Kourkoumelis, N., Manoli, M., Tasiopoulos, A.J., Hadjikakou, S.K.
Journal Paper(2016) Materials Science and Engineering C, 58, pp. 396-408

New antibacterial, non-genotoxic materials, derived from the functionalization of the anti-thyroid drug methimazole with silver ions

Sainis, I., Banti, C.N., Owczarzak, A.M., Kyros, L., Kourkoumelis, N., Kubicki, M., Hadjikakou, S.K.
Journal Paper(2016) Journal of Inorganic Biochemistry (in press)

Advances in the in vivo Raman spectroscopy of malignant skin tumors using portable instrumentation

Kourkoumelis, N., Balatsoukas, I., Moulia, V., Elka, A., Gaitanis, G., Bassukas, I.D.
Journal Paper(2015) International Journal of Molecular Sciences, 16 (7), pp. 14554-14570

Novel mixed metal Ag(I)-Sb(III)-metallotherapeutics of the NSAIDs, aspirin and salicylic acid: Enhancement of their solubility and bioactivity by using the surfactant CTAB

Gkaniatsou, E.I., Banti, C.N., Kourkoumelis, N., Skoulika, S., Manoli, M., Tasiopoulos, A.J., Hadjikakou, S.K.
Journal Paper(2015) Journal of Inorganic Biochemistry, 150, pp. 108-119

Mono-nuclear cis-Pd(II) chloride complex of the thio-nucleotide analogue 5-methyl-thiouracil and its biological activity

Banti, C.N., Charalampou, D.C., Kourkoumelis, N., Owczarzak, A.M., Kubicki, M., Hadjikakou, S.K., Hadjiliadis, N.
Journal Paper(2015) Polyhedron, 87, pp. 251-258

Spectroscopy for biosciences

Kourkoumelis, N.
Journal Paper(2015) Contemporary Physics, 56 (4), pp. 480-482

Assessment of organotins against the linoleic acid, glutathione and CT-DNA

Banti, C.N., Gkaniatsou, E.I., Kourkoumelis, N., Manos, M.J., Tasiopoulos, A.J., Bakas, T., Hadjikakou, S.K.
Journal Paper(2014) Inorganica Chimica Acta, 423 (PB), pp. 98-106

Evaluation of CT-DEA performance on Ca/P ratio assessment in bone apatite using EDX

Hadjipanteli, A., Kourkoumelis, N., Speller, R.
Journal Paper(2014) X-Ray Spectrometry, 43 (5), pp. 286-291

Novel metallo-therapeutics of the NSAID naproxen. Interaction with intracellular components that leads the cells to apoptosis

Banti, C.N., Giannoulis, A.D., Kourkoumelis, N., Owczarzak, A.M., Kubicki, M., Hadjikakou, S.K.
Journal Paper(2014) Dalton Transactions, 43 (18), pp. 6848-6863

A novel silver iodide metalo-drug: Experimental and computational modelling assessment of its interaction with intracellular DNA, lipoxygenase and glutathione

Banti, C.N., Kyros, L., Geromichalos, G.D., Kourkoumelis, N., Kubicki, M., Hadjikakou, S.K.
Journal Paper(2014) European Journal of Medicinal Chemistry, 77, pp. 388-399

Silver(I) compounds of the anti-inflammatory agents salicylic acid and p-hydroxyl-benzoic acid which modulate cell function

Banti, C.N., Giannoulis, A.D., Kourkoumelis, N., Owczarzak, A.M., Kubicki, M., Hadjikakou, S.K.
Journal Paper(2014) Journal of Inorganic Biochemistry, 142, pp. 132-144

Synthesis, characterization, and binding properties towards CT-DNA and lipoxygenase of mixed-ligand silver(I) complexes with 2-mercaptothiazole and its derivatives and triphenylphosphine

Kyros, L., Banti, C.N., Kourkoumelis, N., Kubicki, M., Sainis, I., Hadjikakou, S.K.
Journal Paper(2014) Journal of Biological Inorganic Chemistry, 19 (3), pp. 449-464

The effect of calcium and vitamin D supplementation on osteoporotic rabbit bones studied by vibrational spectroscopy

Lani, A., Kourkoumelis, N., Baliouskas, G., Tzaphlidou, M.
Journal Paper(2014) Journal of Biological Physics, 40 (4), pp. 401-412

A new technique for the assessment of the 3D spatial distribution of the calcium/phosphorus ratio in bone apatite

Hadjipanteli, A., Kourkoumelis, N., Fromme, P., Olivo, A., Huang, J., Speller, R.
Journal Paper(2013) Physiological Measurement, 34 (11), pp. 1399-1410

The impact of the anion size on the crystal packing in 2-mercaptopyrimidine halides; Isostructurality and polymorphism

Owczarzak, A.M., Kourkoumelis, N., Hadjikakou, S.K., Kubicki, M.
Journal Paper(2013) CrystEngComm, 15 (18), pp. 3607-3614

Photo-activated metallotherapeutics: Copper(I) or silver(I) mixed ligand complexes with 2-mercaptopyrimidine and triphenylphosphine

Velalopoulou, A., Batsala, G.K., Kourkoumelis, N., Karkabounas, S., Evangelou, A., Hadjikakou, S.K.
Journal Paper(2013) Medicinal Chemistry Research, 22 (5), pp. 2260-2265

Background estimation of biomedical Raman spectra using a geometric approach

Kourkoumelis, N., Polymeros, A., Tzaphlidou, M.
Book Chapter (2013) Advances in Biomedical Spectroscopy, 7, pp. 243-247

Synthesis, structural characterization and in vitro inhibitory studies against human breast cancer of the bis-(2,6-di-tert-butylphenol)tin(iv) dichloride and its complexes

Shpakovsky, D.B., Banti, C.N., Beaulieu-Houle, G., Kourkoumelis, N., Manoli, M., Manos, M.J., Tasiopoulos, A.J., Hadjikakou, S.K., Milaeva, E.R., Charalabopoulos, K., Bakas, T., Butler, I.S., Hadjiliadis, N.
Journal Paper(2012) Dalton Transactions, 41 (48), pp. 14568-14582

Synthesis and structural characterization of new cu(I) complexes with the antithyroid drug 6-n-propyl-thiouracil. Study of the cu(I)-catalyzed intermolecular cycloaddition of iodonium ylides toward benzo[b]furans with pharmaceutical implementations

Paizanos, K., Charalampou, D., Kourkoumelis, N., Kalpogiannaki, D., Hadjiarapoglou, L., Spanopoulou, A., Lazarou, K., Manos, M.J., Tasiopoulos, A.J., Kubicki, M., Hadjikakou, S.K.
Journal Paper(2012) Inorganic Chemistry, 51 (22), pp. 12248-12259

Continuum determination in spectroscopic data by means of topological concepts and Fourier filtering

Kourkoumelis, N.
Journal Paper(2012) Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 691, pp. 1-4.

Infrared spectroscopic assessment of the inflammation-mediated osteoporosis (IMO) model applied to rabbit bone

Kourkoumelis, N., Lani, A., Tzaphlidou, M.
Journal Paper(2012) Journal of Biological Physics, 38 (4), pp. 623-635

Mixed ligand-silver(I) complexes with anti-inflammatory agents which can bind to lipoxygenase and calf-thymus DNA, modulating their function and inducing apoptosis

Banti, C.N., Giannoulis, A.D., Kourkoumelis, N., Owczarzak, A.M., Poyraz, M., Kubicki, M., Charalabopoulos, K., Hadjikakou, S.K.
Journal Paper(2012) Metallomics, 4 (6), pp. 545-560

Ca/P concentration ratio at different sites of normal and osteoporotic rabbit bones evaluated by Auger and energy dispersive X-ray spectroscopy

Kourkoumelis, N., Balatsoukas, I., Tzaphlidou, M.
Journal Paper(2012) Journal of Biological Physics, 38 (2), pp. 279-291

Inhibition of lipoxygenase (LOX) and anticancer activity caused by gold(I) mixed ligands complexes of triphenylphosphine and thioamides

Georgiou, E., Metsios, A., Kourkoumelis, N., Karkabounas, S., Charalabopoulos, K., Badeka, A., Hadjikakou, S.K.
Journal Paper(2011) Journal of Enzyme Inhibition and Medicinal Chemistry, 26 (4), pp. 592-597

Eye safety related to near infrared radiation exposure to biometric devices

Kourkoumelis, N., Tzaphlidou, M.
Journal Paper(2011) TheScientificWorldJournal, 11, pp. 520-528

Auger electron spectroscopy for the determination of sex and age related Ca/P ratio at different bone sites

Balatsoukas, I., Kourkoumelis, N., Tzaphlidou, M.
Journal Paper(2010) Journal of Applied Physics, 108 (7), art. no. 074701

Medical safety issues concerning the use of incoherent infrared light in biometrics

Kourkoumelis, N., Tzaphlidou, M.
Book Chapter (2010) Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 6005 LNCS, pp. 121-126

The threonine effect on calcium phosphate preparation from a solution containing Ca/P = 1.33 molar ratio

Mahmud, K., Mitsionis, A., Vaimakis, T., Kourkoumelis, N., Trapalis, C.
Journal Paper(2010) Ceramics International, 36 (6), pp. 1893-1899

Multivariate statistical evaluation of bone site and sex as parameters for the Fourier transform infrared spectroscopic study of normal bone

Kourkoumelis, N., Tzaphlidou, M.
Journal Paper(2010) Spectroscopy, 24 (1-2), pp. 99-104

Spectroscopic assessment of normal cortical bone: Differences in relation to bone site and sex

Kourkoumelis, N., Tzaphlidou, M.
Journal Paper(2010) TheScientificWorldJournal, 10, pp. 402-412

Modern Diffraction Methods, edited by E.J. Mittemeijer and U. Welzel

Kourkoumelis, N.
Book Review(2013) Contemporary Physics, 54(2), 134-135

Quantitative Understanding of Biosystems: An Introduction to Biophysics, by Thomas M. Nordlund

Kourkoumelis, N.
Book Review(2012) Contemporary Physics, 53(4), 384-384

Nanocomposite Particles for Bio-Applications: Materials and Bio-Interfaces, by Tito Trindade and Ana L. Daniel da Silva

Kourkoumelis, N.
Book Review(2012) Contemporary Physics, 53(3), 255-256

Research Methods for Science, by Michael P. Marder

Kourkoumelis, N.
Book Review(2012) Contemporary Physics, 53(1), 73-73

Teaching Record

    Postgraduate

  • Present 2015

    Biophysical Methods and Quantitative Structure Activity Relationship (QSAR) modeling

    Medical Chemistry: interdepartmental MSc program organized by School of Health Sciences and Chemistry Dept. | Course Coordinator


  • Undergraduate

  • Present 2009

    Medical Physics (FoM)

    Optics, Microscopy, Non-Ionizing radiation, Thermodynamics of biological systems

  • Present 2009

    Biophysics (DoP)

    Tissues, Proteins, Spectroscopy, Microscopy, Non-Ionizing radiation, Thermodynamics of biological systems, Finite Elements Analysis, Biomaterials

  • 2016 2015

    Biophysics: Special Topics (FoM)

    Tissues, Proteins, Modeling, Microscopy, Thermodynamics of biological systems, Biomaterials


  • Thesis projects

  • 2016 2015

    Theoretical study of the inhibition of three isoforms of lipoxygenase with molecular docking and molecular dynamics

    Petrokilidou Chrysa (Physics)

  • 2015 2014

    Modeling Transport Phenomena in Skin

    Zoupanou Sophia (Physics)

  • 2014 2013

    Theoretical study of DNA interactions with anticancer agents using molecular docking techniques

    Meletiou Anna (Physics)

  • 2013 2012

    The effect of temperature on biological apatite

    Kostopoulou Konstantina (Physics)


  • International Federation of Medical Student Associations (IFMSA) Research Exchange (Students' Supervision)

  • 2015

    FTIR analysis of osteoporotic and normal bone

    Zhang Xianzuo chinese, Nanfang Hospital, Southern Medical University, China

  • 2012

    Spectroscopic studies of bone

    Agniezka Wintrowicz, Medical School, Lodz University, Poland

Teaching History

  • 2008 2005

    Physical Chemistry I and II

    Department of Materials Science and Engineering, UOI (adjunct prof.)

  • 2008 2006

    Characterization techniques: X-ray spectroscopy and X-ray diffraction

    Department of Materials Science and Engineering, UOI (adjunct prof.)

  • 2004 2002

    Object oriented programming

    TEI of Epirus

Software

I am working with powder diffraction related software. Currenty there are two running projects PowDLL (available) and WinPSSP (under development).

  • PowDLL is a .NET dynamic link library used for the interconversion procedure between variable formats of Powder X-Ray files. The DLL is capable of handling the most common file formats (binary and ASCII). The library can be used as a reusable component with any .NET language or as a standalone utility. Read more...

  • WinPSSP, a computer program for the crystal structure solution of molecular materials from X-ray powder diffraction data. Read more...
Check the screenshots below:

Academic Positions

  • Present 2014

    Assistant Professor

    University of Ioannina, School of Health Sciences

  • 2013 2009

    Lecturer

    University of Ioannina, School of Health Sciences

  • 2008 2005

    Adjunct Assistant Professor

    University of Ioannina, Department of Materials Science and Engineering

  • 2008 2003

    Researcher & X-ray Radiation Safety Scientist

    University of Ioannina, Department of Physics (X-ray powder diffraction unit)

Administration / Societies / Misc

  • Member

    Editorial Board 'TheScientificWorld Journal'; Domain: Biophysics (IF: 1.58 (2011))

    Editorial Board 'Journal of Spectroscopy' (IF: 0.53)

    International Center for Diffraction Data (ICDD)

    Elsevier Publishing Advisory Panel

    International Society for Clinical Spectroscopy (CLIRSPEC)

    OSA (Optical Society of America)

    International Osteoporosis Foundation (IOF)

  • Chairman

    1st International Seminar: Postgraduate Programme 'Medical Chemistry', Spectroscopy Session

    University of Ioannina, Greece (2015)

    EURASIA-12 (EuAsC2S) Conference on Chemical Sciences, Physical Methods and Spectroscopy Session

    Corfu, Greece (2012)

  • Erasmus+

    Erasmus+ Programme (Medical Physics). University of Ioanninna (UOI) & University College London (UCL); Agreement initiator

Honors, Awards

  • 2013
    Martin Black Award in Medical Physics (Shortlist)
    Our paper "A new technique for the assessment of the 3D spatial distribution of the calcium/phosphorus ratio in bone apatite" A Hadjipanteli, N Kourkoumelis, P Fromme, A Olivo, J Huang and R Speller (2013) Physiol. Meas. 34, 1399, was: (i) Featured Article (November 2013), (ii) in Highlights of the year 2013 and (iii) Shortlisted for the 2013 Martin Black award (Medical Physics Web Link)
  • 2013
    Best Poster award (ICDD)
    "X-STRIPPING with ME: An improved numerical method for deriving monochromatic datasets from laboratory polychromatic diffractograms based on Maximum Entropy" Robert J. Papoular, Nikolaos Kourkoumelis, ICDD Spring Meeting, 11-15 March 2013, ICDD, Newtown Square, PA, USA
  • 2012
    Journal Cover (Metallomics)
    image
    Our paper "Banti CN, Giannoulis AD, Kourkoumelis N, Owczarzak AM, Poyraz M, Kubicki M, et al. Mixed ligand-silver(I) complexes with anti-inflammatory agents which can bind to lipoxygenase and calf-thymus DNA, modulating their function and inducing apoptosis. Metallomics: integrated biometal science. 2012;4(6):545-60" has made it to the front cover!
  • 2012
    ACD/Labs
    Award from ACD/Labs Inc. (Toronto, ON, Canada) in the form of software (Spectrus Processor) worth of €1000, for my contribution to their software products.
  • 2010
    Frontier Research (American Physical Society)
    Our paper "Balatsoukas I, Kourkoumelis N, Tzaphlidou M. Auger electron spectroscopy for the determination of sex and age related Ca/P ratio at different bone sites. J Appl Phys. 2010;108(7)" was characterized as “frontier research” in the Virtual Journal of Biological Physics Research of the American Physical Society
  • 2004
    European Science Foundation
    European Science Foundation (ESF) Young Scientist Travel Grant Award. 'New theoretical and Spectroscopic Approaches to Chemistry Problems', San Feliu de Guixols, Spain
  • 1997
    State Scholarships Foundation (IKY)
    State Scholarships Foundation (IKY) grant: Universitá degli studi di Padova, Advanced Mössbauer spectroscopy (Prof. U.Russo)

News

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Misc

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At my office

You can find me at my office located at 39°37'06.9"N 20°50'28.3"E

I am at my office every day but please consider an email to fix an appointment.

Projects for senior students

If you are interested in working with me on a student thesis, please fill in this form

If you are interested in MSc or PhD please arrange a meeting by email.