Group

Principal Investigator

  • Nikolaos Kourkoumelis (Assistant Professor)

  • Graduate Students

  • Georgios Rossos (PhD candidate, molecular dynamics)
  • Chrysoula Petrokilidou (MSc candidate, Raman spectroscopy)

  • ...

    Filter by type:

    Sort by year:

    WinPSSP: a revamp of the computer program PSSP and its performance solving the crystal structures of small organic compounds and solids of biological and pharmaceutical interest

    Pagola, S., Polymeros, A., Kourkoumelis, N.
    Journal Paper (2017) Journal of Applied Crystallography, Vol. 50, Issue 1, p293-303

    Osteoporosis and strontium-substituted hydroxyapatites

    Kourkoumelis, N.
    Journal Paper (2016) Annals of translational medicine, Vol.4 Suppl. 1

    Evaluation of the 3D spatial distribution of the Calcium/Phosphorus ratio in bone using computed-tomography dual-energy analysis

    Hadjipanteli, A., Kourkoumelis, N., Fromme, P., Huang, J., Speller, R.
    Journal Paper (2016) Physica Medica: European Journal of Medical Physics, Vol. 32, Issue 1, p162–168

    The effect of irradiance and integration time in in vivo normal skin Raman measurements assessed by multivariate statistical analysis.

    Aspasia Elka, Violetta Moulia, Panagiota Spyridonos, Nikolaos Kourkoumelis
    Journal Paper (2016) Biomedical Spectroscopy and Imaging 5 (2016) 217–223

    Novel bismuth compounds; Synthesis, characterization and biological activity against human adenocarcinoma cells

    Sotiris K Hadjikakou, I. I. Ozturk, C N Banti, Nikolaos Kourkoumelis, Maria Manoli, Anastasios Tasiopoulos, M Arda
    Journal Paper (2016) RSC Advances 03/2016

    New antimony(III) halide complexes with dithiocarbamate ligands derived from thiuram degradation: The effect of the molecule's close contacts on in vitro cytotoxic activity

    Urgut, O.S., Ozturk, I.I., Banti, C.N., Kourkoumelis, N., Manoli, M., Tasiopoulos, A.J., Hadjikakou, S.K.
    Journal Paper(2016) Materials Science and Engineering C, 58, pp. 396-408

    New antibacterial, non-genotoxic materials, derived from the functionalization of the anti-thyroid drug methimazole with silver ions

    Sainis, I., Banti, C.N., Owczarzak, A.M., Kyros, L., Kourkoumelis, N., Kubicki, M., Hadjikakou, S.K.
    Journal Paper(2016) Journal of Inorganic Biochemistry (in press)

    Advances in the in vivo Raman spectroscopy of malignant skin tumors using portable instrumentation

    Kourkoumelis, N., Balatsoukas, I., Moulia, V., Elka, A., Gaitanis, G., Bassukas, I.D.
    Journal Paper(2015) International Journal of Molecular Sciences, 16 (7), pp. 14554-14570

    Novel mixed metal Ag(I)-Sb(III)-metallotherapeutics of the NSAIDs, aspirin and salicylic acid: Enhancement of their solubility and bioactivity by using the surfactant CTAB

    Gkaniatsou, E.I., Banti, C.N., Kourkoumelis, N., Skoulika, S., Manoli, M., Tasiopoulos, A.J., Hadjikakou, S.K.
    Journal Paper(2015) Journal of Inorganic Biochemistry, 150, pp. 108-119

    Mono-nuclear cis-Pd(II) chloride complex of the thio-nucleotide analogue 5-methyl-thiouracil and its biological activity

    Banti, C.N., Charalampou, D.C., Kourkoumelis, N., Owczarzak, A.M., Kubicki, M., Hadjikakou, S.K., Hadjiliadis, N.
    Journal Paper(2015) Polyhedron, 87, pp. 251-258

    Spectroscopy for biosciences

    Kourkoumelis, N.
    Journal Paper(2015) Contemporary Physics, 56 (4), pp. 480-482

    Assessment of organotins against the linoleic acid, glutathione and CT-DNA

    Banti, C.N., Gkaniatsou, E.I., Kourkoumelis, N., Manos, M.J., Tasiopoulos, A.J., Bakas, T., Hadjikakou, S.K.
    Journal Paper(2014) Inorganica Chimica Acta, 423 (PB), pp. 98-106

    Evaluation of CT-DEA performance on Ca/P ratio assessment in bone apatite using EDX

    Hadjipanteli, A., Kourkoumelis, N., Speller, R.
    Journal Paper(2014) X-Ray Spectrometry, 43 (5), pp. 286-291

    Novel metallo-therapeutics of the NSAID naproxen. Interaction with intracellular components that leads the cells to apoptosis

    Banti, C.N., Giannoulis, A.D., Kourkoumelis, N., Owczarzak, A.M., Kubicki, M., Hadjikakou, S.K.
    Journal Paper(2014) Dalton Transactions, 43 (18), pp. 6848-6863

    A novel silver iodide metalo-drug: Experimental and computational modelling assessment of its interaction with intracellular DNA, lipoxygenase and glutathione

    Banti, C.N., Kyros, L., Geromichalos, G.D., Kourkoumelis, N., Kubicki, M., Hadjikakou, S.K.
    Journal Paper(2014) European Journal of Medicinal Chemistry, 77, pp. 388-399

    Silver(I) compounds of the anti-inflammatory agents salicylic acid and p-hydroxyl-benzoic acid which modulate cell function

    Banti, C.N., Giannoulis, A.D., Kourkoumelis, N., Owczarzak, A.M., Kubicki, M., Hadjikakou, S.K.
    Journal Paper(2014) Journal of Inorganic Biochemistry, 142, pp. 132-144

    Synthesis, characterization, and binding properties towards CT-DNA and lipoxygenase of mixed-ligand silver(I) complexes with 2-mercaptothiazole and its derivatives and triphenylphosphine

    Kyros, L., Banti, C.N., Kourkoumelis, N., Kubicki, M., Sainis, I., Hadjikakou, S.K.
    Journal Paper(2014) Journal of Biological Inorganic Chemistry, 19 (3), pp. 449-464

    The effect of calcium and vitamin D supplementation on osteoporotic rabbit bones studied by vibrational spectroscopy

    Lani, A., Kourkoumelis, N., Baliouskas, G., Tzaphlidou, M.
    Journal Paper(2014) Journal of Biological Physics, 40 (4), pp. 401-412

    A new technique for the assessment of the 3D spatial distribution of the calcium/phosphorus ratio in bone apatite

    Hadjipanteli, A., Kourkoumelis, N., Fromme, P., Olivo, A., Huang, J., Speller, R.
    Journal Paper(2013) Physiological Measurement, 34 (11), pp. 1399-1410

    The impact of the anion size on the crystal packing in 2-mercaptopyrimidine halides; Isostructurality and polymorphism

    Owczarzak, A.M., Kourkoumelis, N., Hadjikakou, S.K., Kubicki, M.
    Journal Paper(2013) CrystEngComm, 15 (18), pp. 3607-3614

    Photo-activated metallotherapeutics: Copper(I) or silver(I) mixed ligand complexes with 2-mercaptopyrimidine and triphenylphosphine

    Velalopoulou, A., Batsala, G.K., Kourkoumelis, N., Karkabounas, S., Evangelou, A., Hadjikakou, S.K.
    Journal Paper(2013) Medicinal Chemistry Research, 22 (5), pp. 2260-2265

    Background estimation of biomedical Raman spectra using a geometric approach

    Kourkoumelis, N., Polymeros, A., Tzaphlidou, M.
    Book Chapter (2013) Advances in Biomedical Spectroscopy, 7, pp. 243-247

    Synthesis, structural characterization and in vitro inhibitory studies against human breast cancer of the bis-(2,6-di-tert-butylphenol)tin(iv) dichloride and its complexes

    Shpakovsky, D.B., Banti, C.N., Beaulieu-Houle, G., Kourkoumelis, N., Manoli, M., Manos, M.J., Tasiopoulos, A.J., Hadjikakou, S.K., Milaeva, E.R., Charalabopoulos, K., Bakas, T., Butler, I.S., Hadjiliadis, N.
    Journal Paper(2012) Dalton Transactions, 41 (48), pp. 14568-14582

    Synthesis and structural characterization of new cu(I) complexes with the antithyroid drug 6-n-propyl-thiouracil. Study of the cu(I)-catalyzed intermolecular cycloaddition of iodonium ylides toward benzo[b]furans with pharmaceutical implementations

    Paizanos, K., Charalampou, D., Kourkoumelis, N., Kalpogiannaki, D., Hadjiarapoglou, L., Spanopoulou, A., Lazarou, K., Manos, M.J., Tasiopoulos, A.J., Kubicki, M., Hadjikakou, S.K.
    Journal Paper(2012) Inorganic Chemistry, 51 (22), pp. 12248-12259

    Continuum determination in spectroscopic data by means of topological concepts and Fourier filtering

    Kourkoumelis, N.
    Journal Paper(2012) Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 691, pp. 1-4.

    Infrared spectroscopic assessment of the inflammation-mediated osteoporosis (IMO) model applied to rabbit bone

    Kourkoumelis, N., Lani, A., Tzaphlidou, M.
    Journal Paper(2012) Journal of Biological Physics, 38 (4), pp. 623-635

    Mixed ligand-silver(I) complexes with anti-inflammatory agents which can bind to lipoxygenase and calf-thymus DNA, modulating their function and inducing apoptosis

    Banti, C.N., Giannoulis, A.D., Kourkoumelis, N., Owczarzak, A.M., Poyraz, M., Kubicki, M., Charalabopoulos, K., Hadjikakou, S.K.
    Journal Paper(2012) Metallomics, 4 (6), pp. 545-560

    Ca/P concentration ratio at different sites of normal and osteoporotic rabbit bones evaluated by Auger and energy dispersive X-ray spectroscopy

    Kourkoumelis, N., Balatsoukas, I., Tzaphlidou, M.
    Journal Paper(2012) Journal of Biological Physics, 38 (2), pp. 279-291

    Inhibition of lipoxygenase (LOX) and anticancer activity caused by gold(I) mixed ligands complexes of triphenylphosphine and thioamides

    Georgiou, E., Metsios, A., Kourkoumelis, N., Karkabounas, S., Charalabopoulos, K., Badeka, A., Hadjikakou, S.K.
    Journal Paper(2011) Journal of Enzyme Inhibition and Medicinal Chemistry, 26 (4), pp. 592-597

    Eye safety related to near infrared radiation exposure to biometric devices

    Kourkoumelis, N., Tzaphlidou, M.
    Journal Paper(2011) TheScientificWorldJournal, 11, pp. 520-528

    Auger electron spectroscopy for the determination of sex and age related Ca/P ratio at different bone sites

    Balatsoukas, I., Kourkoumelis, N., Tzaphlidou, M.
    Journal Paper(2010) Journal of Applied Physics, 108 (7), art. no. 074701

    Medical safety issues concerning the use of incoherent infrared light in biometrics

    Kourkoumelis, N., Tzaphlidou, M.
    Book Chapter (2010) Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 6005 LNCS, pp. 121-126

    The threonine effect on calcium phosphate preparation from a solution containing Ca/P = 1.33 molar ratio

    Mahmud, K., Mitsionis, A., Vaimakis, T., Kourkoumelis, N., Trapalis, C.
    Journal Paper(2010) Ceramics International, 36 (6), pp. 1893-1899

    Multivariate statistical evaluation of bone site and sex as parameters for the Fourier transform infrared spectroscopic study of normal bone

    Kourkoumelis, N., Tzaphlidou, M.
    Journal Paper(2010) Spectroscopy, 24 (1-2), pp. 99-104

    Spectroscopic assessment of normal cortical bone: Differences in relation to bone site and sex

    Kourkoumelis, N., Tzaphlidou, M.
    Journal Paper(2010) TheScientificWorldJournal, 10, pp. 402-412

    Modern Diffraction Methods, edited by E.J. Mittemeijer and U. Welzel

    Kourkoumelis, N.
    Book Review(2013) Contemporary Physics, 54(2), 134-135

    Quantitative Understanding of Biosystems: An Introduction to Biophysics, by Thomas M. Nordlund

    Kourkoumelis, N.
    Book Review(2012) Contemporary Physics, 53(4), 384-384

    Nanocomposite Particles for Bio-Applications: Materials and Bio-Interfaces, by Tito Trindade and Ana L. Daniel da Silva

    Kourkoumelis, N.
    Book Review(2012) Contemporary Physics, 53(3), 255-256

    Research Methods for Science, by Michael P. Marder

    Kourkoumelis, N.
    Book Review(2012) Contemporary Physics, 53(1), 73-73

    Teaching Record

      Postgraduate

    • Present 2015

      Biophysical Methods and Quantitative Structure Activity Relationship (QSAR) modeling

      Medical Chemistry: interdepartmental MSc program organized by School of Health Sciences and Chemistry Dept. | Course Coordinator


    • Undergraduate

    • Present 2009

      Medical Physics (FoM)

      Optics, Microscopy, Non-Ionizing radiation, Thermodynamics of biological systems

    • 2016 2009

      Biophysics (DoP)

      Tissues, Proteins, Spectroscopy, Microscopy, Non-Ionizing radiation, Thermodynamics of biological systems

    • Present 2015

      Biophysics: Special Topics (FoM)

      Tissues, Proteins, Electron Microscopy, Thermodynamics of biological systems, Biomaterials


    • Thesis projects

    • 2017 2016

      Bioavailability studies of common drugs using X-ray powder diffraction

      Livitsanou Chrysa (Physics)

    • 2016 2015

      Theoretical study of the inhibition of three isoforms of lipoxygenase with molecular docking and molecular dynamics

      Petrokilidou Chrysa (Physics)

    • 2015 2014

      Modeling Transport Phenomena in Skin

      Zoupanou Sophia (Physics)

    • 2014 2013

      Theoretical study of DNA interactions with anticancer agents using molecular docking techniques

      Meletiou Anna (Physics)

    • 2013 2012

      The effect of temperature on biological apatite

      Kostopoulou Konstantina (Physics)


    • International Federation of Medical Student Associations (IFMSA) Research Exchange (Students' Supervision)

    • 2015

      FTIR analysis of osteoporotic and normal bone

      Zhang Xianzuo chinese, Nanfang Hospital, Southern Medical University, China

    • 2012

      Spectroscopic studies of bone

      Agniezka Wintrowicz, Medical School, Lodz University, Poland

    Teaching History

    • 2008 2005

      Physical Chemistry I and II

      Department of Materials Science and Engineering, UOI (adjunct prof.)

    • 2008 2006

      Characterization techniques: X-ray spectroscopy and X-ray diffraction

      Department of Materials Science and Engineering, UOI (adjunct prof.)

    • 2004 2002

      Object oriented programming

      TEI of Epirus

    Software

    I am working with powder diffraction related software. Currenty there are two running projects PowDLL (available) and WinPSSP (under development).

    • PowDLL is a .NET dynamic link library used for the interconversion procedure between variable formats of Powder X-Ray files. The DLL is capable of handling the most common file formats (binary and ASCII). The library can be used as a reusable component with any .NET language or as a standalone utility. Read more...

    • WinPSSP, a computer program for the crystal structure solution of molecular materials from X-ray powder diffraction data. Read more...
    Check the screenshots below:

    Academic Positions

    • Present 2014

      Assistant Professor

      University of Ioannina, School of Health Sciences

    • 2013 2009

      Lecturer

      University of Ioannina, School of Health Sciences

    • 2008 2005

      Adjunct Assistant Professor

      University of Ioannina, Department of Materials Science and Engineering

    • 2008 2003

      Researcher & X-ray Radiation Safety Scientist

      University of Ioannina, Department of Physics (X-ray powder diffraction unit)

    Administration / Societies / Misc

    • Member

      Editorial Board 'TheScientificWorld Journal'; Domain: Biophysics (IF: 1.58 (2011))

      Editorial Board 'Journal of Spectroscopy' (IF: 0.53)

      International Center for Diffraction Data (ICDD)

      Elsevier Publishing Advisory Panel

      International Society for Clinical Spectroscopy (CLIRSPEC)

      OSA (Optical Society of America)

      International Osteoporosis Foundation (IOF)

    • Chairman

      1st International Seminar: Postgraduate Programme 'Medical Chemistry', Spectroscopy Session

      University of Ioannina, Greece (2015)

      EURASIA-12 (EuAsC2S) Conference on Chemical Sciences, Physical Methods and Spectroscopy Session

      Corfu, Greece (2012)

    • Erasmus+

      Erasmus+ Programme (Medical Physics). University of Ioanninna (UOI) & University College London (UCL); Agreement initiator

    Honors, Awards

    • 2013
      Martin Black Award in Medical Physics (Shortlist)
      Our paper "A new technique for the assessment of the 3D spatial distribution of the calcium/phosphorus ratio in bone apatite" A Hadjipanteli, N Kourkoumelis, P Fromme, A Olivo, J Huang and R Speller (2013) Physiol. Meas. 34, 1399, was: (i) Featured Article (November 2013), (ii) in Highlights of the year 2013 and (iii) Shortlisted for the 2013 Martin Black award (Medical Physics Web Link)
    • 2013
      Best Poster award (ICDD)
      "X-STRIPPING with ME: An improved numerical method for deriving monochromatic datasets from laboratory polychromatic diffractograms based on Maximum Entropy" Robert J. Papoular, Nikolaos Kourkoumelis, ICDD Spring Meeting, 11-15 March 2013, ICDD, Newtown Square, PA, USA
    • 2012
      Journal Cover (Metallomics)
      image
      Our paper "Banti CN, Giannoulis AD, Kourkoumelis N, Owczarzak AM, Poyraz M, Kubicki M, et al. Mixed ligand-silver(I) complexes with anti-inflammatory agents which can bind to lipoxygenase and calf-thymus DNA, modulating their function and inducing apoptosis. Metallomics: integrated biometal science. 2012;4(6):545-60" has made it to the front cover!
    • 2012
      ACD/Labs
      Award from ACD/Labs Inc. (Toronto, ON, Canada) in the form of software (Spectrus Processor) worth of €1000, for my contribution to their software products.
    • 2010
      Frontier Research (American Physical Society)
      Our paper "Balatsoukas I, Kourkoumelis N, Tzaphlidou M. Auger electron spectroscopy for the determination of sex and age related Ca/P ratio at different bone sites. J Appl Phys. 2010;108(7)" was characterized as “frontier research” in the Virtual Journal of Biological Physics Research of the American Physical Society
    • 2004
      European Science Foundation
      European Science Foundation (ESF) Young Scientist Travel Grant Award. 'New theoretical and Spectroscopic Approaches to Chemistry Problems', San Feliu de Guixols, Spain
    • 1997
      State Scholarships Foundation (IKY)
      State Scholarships Foundation (IKY) grant: Universitá degli studi di Padova, Advanced Mössbauer spectroscopy (Prof. U.Russo)

    Research Grants

    • image

      European Union (European Regional Development Fund- ERDF) and Greek national funds through the Operational Program "THESSALY- MAINLAND GREECE AND EPIRUS-2007-2013" of the National Strategic Reference Framework (NSRF 2007-2013) | Grant

      Principal Investigator

    At my office

    You can find me at my office located at 39°37'06.9"N 20°50'28.3"E

    I am at my office every day but please consider an email to fix an appointment.

    Projects for senior students

    If you are interested in working with me on a student thesis, please fill in this form

    If you are interested in MSc or PhD please arrange a meeting by email.