Research

Group

Lab members

Aristotelis Astrinidis
Alexandra Bisioti
Artemi Gounari-Papaioannou

 

Past lab members

Past lab members

Andrew M. Cox, BA, MS
Research Assistant I (2007-2009)

BS Biology/Sec.Ed. 2003 - Marist
MA Cell/Dev.Biology 2007 - Villanova
Currently: PharmD student - University of Pittsburgh

Projects

I. Pharmacological inhibition of PLK1


 
 

Abstracts

 
 

2010

Valianou M, Cox AM, Nakao Y, Kasikara C, and Astrinidis A. Pharmacologic inhibition of PLK1 decreases the survival of TSC1 and TSC2 deficient cells. Discovery Day Drexel University College of Medicine, 7 October 2010

 

2010

Valianou M, Cox AM and Astrinidis A. Pharmacologic inhibition of polo-like kinase 1 (PLK1) decreases the viability and survival of TSC1 and TSC2 null cells via induction of autophagy. The LAM Foundation 2010 International Conference, Cinciatti OH, April 9-11, 2010

 

2009

Valianou M, Cox AM and Astrinidis A. Pharmacologic inhibition of polo-like kinase 1 (PLK1) decreases the survival of TSC1 and TSC2 deficient cells. Discovery Day Drexel University College of Medicine, 7 October 2009, Philadelphia PA [Outstanding Poster Presentation Award]

 

2009

Cox AM and Astrinidis A. Pharmacologic inhibition of polo-like kinase 1 (PLK1) decreases the survival of hamartin and tuberin deficient cells. International Tuberous Sclerosis Complex (TSC) Conference: From DNA to Therapeutics , 23-26 September 2009, Bloomington IL

 

2008

Cox AM, Koutroukides T, Kennedy A, Astrinidis A. The tuberous sclerosis complex proteins regulate centrosome amplification, mitotic progression and cytokinesis. Breast Cancer Interdisciplinary Scientific Symposium Drexel University College of Medicine, 17 May 2008, Philadelphia PA

 


Awards

 

 

2009

Outstanding Poster Presentation, 1st place - Discovery Day Drexel University College of Medicine




 

Laia Gomez-Baldo, BS MS PhD
Visiting Fellow (2008)

BS Biology 2002 - U. Barcelona
MS Exp. Biology 2003 - U. Barcelona
PhD 2010 - U. Barcelona
Postdoc 2010 - ICO

Projects
I. TSC-associated interactome

Pubmed link to publications


 

Publications

 
 

2010

Gómez-Baldó L., Schmidt S., Maxwell C.A., Bonifaci N., Gabaldón T., Vidalain P-O., Senapedis W., Kletke A., Rosing M., Barnekow A., Rottapel R., Capellá G., Vidal M., Astrinidis A.§, Piekorz R.P.§, Pujana M.A. TACC3-TSC2 maintains nuclear envelope structure and controls cell division. Cell Cycle 9(6): 1143-1155

 


Abstracts

 
 

2009

Gómez L, Astrinidis A, Maxwell CA, Piekorz R, Pujana M-A. From TACC3-interactome mapping to TSC2 cancer molecular dependencies. Abcam Mitosis and Cancer Symposium, 26-27 February 2009, Amsterdam, The Netherlands

 

2009

Gómez-Baldó L, Schmidt S, Maxwell CA, Bonifaci N, Gabaldón T, Vidalain P-O, Senapedis W, Kletke A, Rosing M, Barnekow A, Rottapel R, Capellá G, Vidal M, Astrinidis A, Piekorz RP, Pujana MA. TACC3-TSC2 maintain nuclear envelope structure and control cell division. International Tuberous Sclerosis Complex (TSC) Conference: From DNA to Therapeutics , 23-26 September 2009, Bloomington IL

 


Fellowships

 
 

2008

Agència de Gestió d'Ajuts Universitaris i de Recerca, Spain

 


Awards

 

 

2009

Travel Award - International Tuberous Sclerosis Complex (TSC) Conference: From DNA to Therapeutics, 23-26 September 2009, Bloomington IL




 

Eugene Beaird, BS
Summer Research Fellow (2009)

BS Mol. Cellular and Dev. Biology 2008 - U. Washington
Currently: Medical Student - Drexel Medicine

Projects
I. Mitotic phosphorylation of hamartin and tuberin


 
 

Abstracts

 
 

2009

Beaird E, Valianou M and Astrinidis A. PLK1-dependent phosphorylation of hamartin and tuberin. Discovery Day Drexel University College of Medicine, 7 October 2009

 


Fellowships

 

 

2009

Medical Student Summer Research Program




 

Jeffrey Wang
Undergraduate Research Assistant (2009-2010)
Department of Biology
Drexel University

Projects
I. Drug screen for TSC/LAM




 

Farah Noorani
Undergraduate Research Assistant (2009-2010)
Department of Biology
Drexel University

Projects
I. Genotoxic/oxidative stress and mTOR pathway


 



 

Yuka Nakao
Undergraduate Research Assistant (2010)
Department of Biology
Drexel University

Projects
I. Drug screen for TSC/LAM


 
 

Abstracts

 
 

2011

Spadidea P, Kasikara C, Nakao Y, Astrinidis A. Screen of FDA-approved drugs as a therapeutic approach for sporadic pulmonary Lymphangioleiomyomatosis and Tuberous Sclerosis Complex. The LAM Foundation International Research Conference, 8-10 April 2011, Cincinnati OH

 

2010

Nakao Y, Kasikara C, and Astrinidis A. Screen of FDA-approved drugs as a therapeutic approach for Tuberous Sclerosis Complex. Discovery Day Drexel University College of Medicine, 7 October 2010

 

2010

Valianou M, Cox AM, Nakao Y, Kasikara C, and Astrinidis A. Pharmacologic inhibition of PLK1 decreases the survival of TSC1 and TSC2 deficient cells. Discovery Day Drexel University College of Medicine, 7 October 2010




 

Canan Kasikara
International Student Intern (2010)
Science, Molecular Biology and Genetics
Bilkent University, Ankara, Turkey

Projects
I. Drug screen for TSC/LAM


 
 

Abstracts

 
 

2010

Nakao Y, Kasikara C, and Astrinidis A. Screen of FDA-approved drugs as a therapeutic approach for Tuberous Sclerosis Complex. Discovery Day Drexel University College of Medicine, 7 October 2010

 

2010

Valianou M, Cox AM, Nakao Y, Kasikara C, and Astrinidis A. Pharmacologic inhibition of PLK1 decreases the survival of TSC1 and TSC2 deficient cells. Discovery Day Drexel University College of Medicine, 7 October 2010



 

Matthildi Valianou, BS
Research Assistant II (2009-2011)

BS Biology 1995 - Aristotle University of Thessaloniki

Projects
I. Pharmacologic inhibition of PLK1
II. Mitotic phosphorylation of hamartin and tuberin

Pubmed link to publications


Matthildi Valianou
 

Abstracts

 
 

2011

Valianou M, Astrinidis A. TSC1 and TSC2 null cells exhibit higher sensitivity to autophagy and apoptosis upon PLK1 inhibition - implications for therapy?  The LAM Foundation International Research Conference, Cincinnati OH, 8-10 April 2011

 

2010

Valianou M, Cox AM, Nakao Y, Kasikara C, and Astrinidis A. Pharmacologic inhibition of PLK1 decreases the survival of TSC1 and TSC2 deficient cells. Discovery Day Drexel University College of Medicine, 7 October 2010

 

2010

Valianou M, Cox AM and Astrinidis A. Pharmacologic inhibition of polo-like kinase 1 (PLK1) decreases the viability and survival of TSC1 and TSC2 null cells via induction of autophagy. The LAM Foundation 2010 International Conference, Cinciatti OH, April 9-11, 2010

 

2009

Valianou M, Cox AM and Astrinidis A. Pharmacologic inhibition of polo-like kinase 1 (PLK1) decreases the survival of TSC1 and TSC2 deficient cells. Discovery Day Drexel University College of Medicine, 7 October 2009 [Oustanding Poster Presentation Award]

 

2009

Beaird E, Valianou M and Astrinidis A. PLK1-dependent phosphorylation of hamartin and tuberin. Discovery Day Drexel University College of Medicine, 7 October 2009

 


Awards

 
 

2009

Outstanding Poster Presentation, 1st place - Discovery Day Drexel University College of Medicine



 

Panagiota Spadidea, BS
Lab Assistant II (2010-2011)

BS Biology 2009 - U Patras

Projects
I. Drug screen for TSC/LAM

Pubmed links to publications


 
 

Abstracts

 
 

2011

Spadidea P, Kasikara C, Nakao Y, Astrinidis A. Screen of FDA-approved drugs as a therapeutic approach for sporadic pulmonary Lymphangioleiomyomatosis and Tuberous Sclerosis Complex. The LAM Foundation International Research Conference, Cincinnati OH, 8-10 April 2011



 

Shannon Hartley, BS
Lab Assistant II (2010-2011)

BS Biology 2011 - Gettysburg College

Projects
I. Drug screen for TSC/LAM


 


 

Benjamin Pichette, BS
Lab Assistant II (2011-2012)

BS Chemical Engineering 2007 - Wayne State University
MS Engineering in Bioengineering 2011- University of Pennsylvania

Projects
I. Pharmacologic inhibition of PLK1
II. Mitotic phosphorylation of hamartin and tuberin

Pubmed link to publications


 


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