Background

• Tuberous Sclerosis Complex
  Lymphangioleiomyomatosis
• TSC1 and TSC2
• Mitotic phosphorylation of TSC1
• Centrosomes
• Ploidy
• Funding and awareness

Current projects

• Role of PLK1-TSC1 interaction in TSC
• Drug screen for TSC

Mutations in the tumor suppressor genes TSC1 and TSC2 in Tuberous Sclerosis Complex (TSC) and pulmonary Lymphangioleiomyomatosis (LAM) lead to aberrant activation of the AKT/mTOR pathway, frequently dysregulated also in other forms of cancer. Our goal is to elucidate novel mechanisms and signaling pathways leading to mTOR-dependent tumor formation with the potential for therapeutic intervention. Our work focuses on the functions of the proteins involved in TSC/LAM pathogenesis with regards to cell division.