Charalampos Labrakakis

Lecturer in Neurophysiology

Department of Biological & Applic.Technol.
Univeristy of Ioannina
+30-265100-7395
clabrak@cc.uoi.gr
Student office hours: Mondays, 14:00-16:00

Research Interests

The major interest of my research lies in the elucidation of the nociceptive circuit in the spinal dorsal horn. By studying the properties of synapting transmission I am trying to understand the changes that lead to increased network excitability that governs many pathological pain states. Additional research is focused on the properties of GABAA-receptors, GABAergic synaptic transmission and their role in neurological disorders.

Education

PhD in Neurobiology, Humboldt University Berlin/Max-Delbruck-Center for Molecular Medicine
BSc in Biology, Aristotle University of Thessaloniki

Experience

Department of Physiology and Cellular Biophysics, Columbia University, New York
Division Cellular Neurosciences, Centre de recherche Universite Laval-Robert Giffard, Canada

Selected Publications

Bonin, R., Labrakakis, C., Eng, D.G., Whissell, P.D., De Koninck, Y. and Orser, B.A. (2011) Pharmacological enhancement of d-subunit-containing GABAA receptors that generate a tonic inhibitory conductance in spinal neurons attenuates acute nociception in mice. Pain 152:1317-1326

Labrakakis C., Ferrini F. and De Koninck Y. Mechanisms of Plasticity of Inhibition in Chronic Pain Conditions. In "Inhibitory Synaptic Plasticity", Woodin M.A. and Maffei A. (Eds). Springer-Verlag, New York, 2011. [PDF]

Labrakakis, C., Lorenzo, L.E., Ribeiro-da-Silva, A. and De Koninck, Y. (2009) Inhibitory coupling between inhibitory interneurons in the spinal cord dorsal horn. Molecular Pain, 5:24 doi:10.1186/1744-8069-5-24 [PDF]

Labrakakis, C. and MacDermott, A.B. (2003) Neurokinin receptor 1-expressing spinal cord neurons in lamina I and III/IV of postnatal rats receive inputs from capsaicin sensitive fibers. Neurosci Lett. 352: 121-124

Labrakakis C., Tong, C.K., Weissman T., Torsney, C. and MacDermott, A.B, (2003) Localization and function of ATP and GABAA receptors expressed by nociceptors and other postnatal sensory neurons in rat. J. Physiol (London) 549: 131-142.

Labrakakis, C., Gerstner, E. and MacDermott A.B. (2000) Adenosine triphosphate-evoked currents in cultured dorsal root ganglion neurons obtained from rat embryos: Desensitization kinetics and modulation of glutamate release. Neuroscience 101: (4) 1117-1126

CV Research Teaching