Dr S K Hadjikakou

Research Interests

Research Projects

List of Publications

Chapters in Books



Book Authorship






Dr. Sotiris K. Hadjikakou,


Laboratory of Biological Inorganic Chemistry


Department of Chemistry University of Ioannina, Greece

tel. xx-30-26510-08374, xx-30-26510-08362.

Fax xx-30-26510-08786




Coordinator of the Graduate Program in Biological Inorganic Chemistry



Institute of Materials Science  and Computing (I.M.S.C.)



Research Ranking (December 6th, 2023)

Among Top Chemistry Scientists in Greece

Among the scientists who ranked in the 2% or above in the sub-field in the calendar year 2022




Elsevier: Inorganic Chemistry Communications (Inorg Chem Comm)


Member of the editorial boards:

[1] Taylor and Francis-Phosphorus, Sulfur, and Silicon and the Related Elements (

[2] MDPI-International Journal of Molecular Science ( )
[3] MDPI-Antibiotics (
[4] Journal of Balkan Science and Technology (JBST) (
[5] Frontiers in Chemical Biology (
[6] Journal of the Association of Greek Chemists (

[7] COSTCA22125 (National Representative)- - Precision medicine in biliary tract cancer (Precision-BTC-Network) (




Guest Editor in the Special Issues:

IJMS (MDPI): Recent Advances in Metal Based Drugs

IJMS (MDPI):Metal Complex Interactions with Nucleic Acids and/or DNA

Molecules (MDPI): Antimicrobial Materials with Medical Applications

IJMS (MDPI): Antimicrobial Materials with Medical Applications

Antibiotics (MDPI): Silver and Gold Compounds as Antibiotics "



Member of Scientific Societies

[1] Member of the Greek Chemists Association (AGC) (Greek branch of the European Chemical Society (EuChemS))

[2] Member of the Hellenic Society of Medicinal Chemistry (HSMC) (Greek branch of the European Federation of Medicinal Chemistry and Chemical Biology (EFMC))

[3] Member of the Society of Biological Inorganic Chemistry (SBIC)


Member of the International Advisory Boards of the Scientific conference

[1] International Meeting on Halogen Chemistry HALCHEM, 2006-

[2] Eurasia Conference on Chemical Sciences EuAsC2S, 2012-

[3] International Symposium on Applied Bioinorganic Chemistry ISABC, 2017-


Member of Scientific Networks

[1] COST Action CM1105 "Functional metal complexes that bind to biomolecule", Member of the Working Group "WG 4: Interactions of metallo-drugs on the cellular level" at

[2] COST Action CA15114 (National Representative) «Anti-Microbial Coating Innovations to Prevent Infectious Diseases (AMICI) Member of the Working Group "WG 1: Antimicrobial Materials Safe-by-Design"

[3] COST Action CIG15114 “e-PlatformePlatform for a “test bed” tool across EU for antimicrobial coating solutions in health care entering to the market”

[4] COST Action CA17104 (STRATAGEM): “New diagnostic and therapeutic tools against multidrug resistant tumours”

[5]COST Action CA21145 - European Network for diagnosis and treatment of antibiotic-resistant bacterial infections (EURESTOP)

[6] COST Action CA21115 (National Representative)- Iron-sulphur (FeS) clusters: from chemistry to immunology (FeSImm ChemNet)"






New Apoptosis Inducers Containing Anti-inflammatory Drugs and

Pnictogen Derivatives: A New Strategy in the Development of

Mitochondrial Targeting Chemotherapeutics

Christina N. Banti, Constantina Papatriantafyllopoulou, Christina Papachristodoulou,

Antonios G. Hatzidimitriou, and Sotiris K. Hadjikakou, J. Med. Chem. 2023, 66, 41314149



Our protocol is reprinted in Microbiology Bio-protocol Selections 2022, a curated series of the 26 methods most used by Bio-protocol’s community over the past year 2021.



The research Project of our group: Design and development of new formulations based on natural products as additives in contact lenses, for the treatment of microbial keratitis is Co‐financed by the European Regional Development Fund of the European Union and Greek national funds through the Operational Program Competitiveness, Entrepreneurship and Innovation, under the call RESEARCH– CREATE - INNOVATE (project code:Τ1EDK-02990)»



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Hydrogels containing water soluble conjugates of silver(I) ions with amino acids, metabolites or natural products for non infectious contact lenses

C. N. Banti, M. Kapetana, C. Papachristodoulou, C. P. Raptopoulou, V. Psycharis, P. Zoumpoulakis, T. Mavromoustakos and S. K. Hadjikakou Dalton Trans., 2021, 50, 13712–13727


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Ciprofloxacin conjugated to diphenyltin(IV): a novel formulation with enhanced antimicrobial activity

M.P. Chrysouli, C.N. Banti, N. Kourkoumelis, E.E. Moushi, A.J. Tasiopoulos, A. Douvalis, C. Papachristodoulou, A.G. Hatzidimitriou, T. Bakas and S.K. Hadjikakou

Dalton Trans., 2020, 49, 11522–11535


Synthesis, Structural Characterization and Cytostatic Properties of N,N-Dicyclohexyldithiooxamide Complexes of Antimony(III) Halides (SbX3, X: Br or I)

I.I. Ozturk, O.S. Urgut, C.N. Banti, N. Kourkoumelic, A.M. Owczarzak, M. Kubicki, and S.K. Hadjikakou

Polyhedron Volume 70, 9 March 2014, Pages 172–179


Mixed ligands silver(I) complexes with anti-inflammatory agents which can bind to lipoxygenase and calf thymus-DNA, modulating their function, inducing apoptosis.

C.N. Banti, A. D. Giannoulis, N. Kourkoumelis, A. M. Owczarzak, M. Poyraz, M. Kubicki, K. Charalabopoulos and S. K. Hadjikakou

Metallomics, 2012, 2012, 4, 545–560



























Our recent papers:

pHEMA@AGMNA-1: A novel material for the development of antibacterial contact lens

A.K. Rossos, C.N. Banti, A. Kalampounias, C. Papachristodoulou, K. Kordatos, P. Zoumpoulakis, T. Mavromoustakos, N. Kourkoumelis, S.K. Hadjikakou

Materials Science & Engineering C 111 (2020) 110770







Conjugation of Penicillin-G with Silver(I) Ions Expands Its Antimicrobial Activity against Gram Negative Bacteria

Ioannis Ketikidis, Christina N. Banti, Nikolaos Kourkoumelis, Constantinos G. Tsiafoulis, Christina Papachristodoulou, Angelos G. Kalampounias and Sotiris K. Hadjikakou

Antibiotics 2020, 9, 25; doi:10.3390


Diclofenac conjugates with biocides through silver(I) ions (CoMeD's); Development of a reliable model for the prediction of anti-proliferation of NSAID's-silver formulations.

Christina N. Banti, Antonios G. Hatzidimitriou, Nikolaos Kourkoumelis, Sotiris K. Hadjikakou

Journal of Inorganic Biochemistry 194 (2019) 7–18