Dr S K Hadjikakou

Research Interests

Research Projects

List of Publications

Chapters in Books



Book Authorship





Dr. Sotiris K. Hadjikakou,


Laboratory of Biological Inorganic Chemistry

Department of Chemistry

University of Ioannina, Greece

tel. xx-30-26510-08374, xx-30-26510-08362.

Fax xx-30-26510-08786



Institute of Materials Science  and Computing (I.M.S.C.)


Research Ranking (December 6th, 2021)

Among Top Chemistry Scientists in Greece


Coordinator of the Graduate Program in Biological Inorganic Chemistry


Member of Scientific Societies

Association of Greek Chemists (AGC)

European Chemical Society (EuChemS)

Member of the Hellenic Society of Medicinal Chemistry (HSMC)

European Federation of Medicinal Chemistry and Chemical Biology (EFMC)

Member of the Society of Biological Inorganic Chemistry (SBIC)


Member of the editorial boards:

Elsevier: Journal of Inorganic Biochemistry (JIB)

MDPI: International Journal of Molecular Sciences-Biochemistry (IJMS)

MDPI: Antibiotics (Antibiotics)


Guest Editor in the Special Issues:

IJMS (MDPI): Recent Advances in Metal Based Drugs

IJMS (MDPI):Metal Complex Interactions with Nucleic Acids and/or DNA

Molecules (MDPI): Antimicrobial Materials with Medical Applications

IJMS (MDPI): Antimicrobial Materials with Medical Applications

Antibiotics (MDPI): Silver and Gold Compounds as Antibiotics "


Member of Scientific Networks

[1] COST Action CM1105 "Functional metal complexes that bind to biomolecule", Member of the Working Group "WG 4: Interactions of metallo-drugs on the cellular level" at

[2] COST Action CA15114 (National Representative) «Anti-Microbial Coating Innovations to Prevent Infectious Diseases (AMICI) Member of the Working Group "WG 1: Antimicrobial Materials Safe-by-Design"

[3] COST Action CIG15114 “e-PlatformePlatform for a “test bed” tool across EU for antimicrobial coating solutions in health care entering to the market”

[4] COST Action CA17104 (STRATAGEM): “New diagnostic and therapeutic tools against multidrug resistant tumours”

[5]COST Action CA21145 - European Network for diagnosis and treatment of antibiotic-resistant bacterial infections (EURESTOP)

[6] COST Action CA21115 (National Representative)- Iron-sulphur (FeS) clusters: from chemistry to immunology (FeSImm ChemNet)"




Our protocol is reprinted in Microbiology Bio-protocol Selections 2022, a curated series of the 26 methods most used by Bio-protocol’s community over the past year 2021.



Description automatically generated

Hydrogels containing water soluble conjugates of silver(I) ions with amino acids, metabolites or natural products for non infectious contact lenses

C. N. Banti, M. Kapetana, C. Papachristodoulou, C. P. Raptopoulou, V. Psycharis, P. Zoumpoulakis, T. Mavromoustakos and S. K. Hadjikakou Dalton Trans., 2021, 50, 13712–13727


A picture containing text, screenshot

Description automatically generated

Ciprofloxacin conjugated to diphenyltin(IV): a novel formulation with enhanced antimicrobial activity

M.P. Chrysouli, C.N. Banti, N. Kourkoumelis, E.E. Moushi, A.J. Tasiopoulos, A. Douvalis, C. Papachristodoulou, A.G. Hatzidimitriou, T. Bakas and S.K. Hadjikakou

Dalton Trans., 2020, 49, 11522–11535


Synthesis, Structural Characterization and Cytostatic Properties of N,N-Dicyclohexyldithiooxamide Complexes of Antimony(III) Halides (SbX3, X: Br or I)

I.I. Ozturk, O.S. Urgut, C.N. Banti, N. Kourkoumelic, A.M. Owczarzak, M. Kubicki, and S.K. Hadjikakou

Polyhedron Volume 70, 9 March 2014, Pages 172–179


Mixed ligands silver(I) complexes with anti-inflammatory agents which can bind to lipoxygenase and calf thymus-DNA, modulating their function, inducing apoptosis.

C.N. Banti, A. D. Giannoulis, N. Kourkoumelis, A. M. Owczarzak, M. Poyraz, M. Kubicki, K. Charalabopoulos and S. K. Hadjikakou

Metallomics, 2012, 2012, 4, 545–560



















Our recent papers:

pHEMA@AGMNA-1: A novel material for the development of antibacterial contact lens

A.K. Rossos, C.N. Banti, A. Kalampounias, C. Papachristodoulou, K. Kordatos, P. Zoumpoulakis, T. Mavromoustakos, N. Kourkoumelis, S.K. Hadjikakou

Materials Science & Engineering C 111 (2020) 110770






Conjugation of Penicillin-G with Silver(I) Ions Expands Its Antimicrobial Activity against Gram Negative Bacteria

Ioannis Ketikidis, Christina N. Banti, Nikolaos Kourkoumelis, Constantinos G. Tsiafoulis, Christina Papachristodoulou, Angelos G. Kalampounias and Sotiris K. Hadjikakou

Antibiotics 2020, 9, 25; doi:10.3390


Diclofenac conjugates with biocides through silver(I) ions (CoMeD's); Development of a reliable model for the prediction of anti-proliferation of NSAID's-silver formulations.

Christina N. Banti, Antonios G. Hatzidimitriou, Nikolaos Kourkoumelis, Sotiris K. Hadjikakou

Journal of Inorganic Biochemistry 194 (2019) 7–18